Details

Autor(en) / Beteiligte

• Heijmans, J
• Büller, N V J A
• Hoff, E
• Dihal, A A
• van der Poll, T
• van Zoelen, M A D
• Bierhaus, A
• Biemond, I
• Hardwick, J C H
• Hommes, D W
• Muncan, V
• van den Brink, G R

Titel

Rage signalling promotes intestinal tumourigenesis

Ist Teil von

• Oncogene, 2013-02, Vol.32 (9), p.1202-1206

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis.