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New reference equations to improve interpretation of infant lung function
Pediatric pulmonology, 2013-04, Vol.48 (4), p.370-380
Nguyen, The Thanh Diem
Hoo, Ah-Fong
Lum, Sooky
Wade, Angie
Thia, Lena P.
Stocks, Janet
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Nguyen, The Thanh Diem
Hoo, Ah-Fong
Lum, Sooky
Wade, Angie
Thia, Lena P.
Stocks, Janet
Titel
New reference equations to improve interpretation of infant lung function
Ist Teil von
Pediatric pulmonology, 2013-04, Vol.48 (4), p.370-380
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Rationale With increasing use of infant pulmonary function tests (IPFTs) in both clinical and research studies, appropriate interpretation of results is essential. Objectives To investigate the potential bias associated with “normalising” IPF by expressing results as a ratio of body size and to develop reference ranges for tidal breathing parameters, passive respiratory mechanics (compliance [Crs] and resistance [Rrs]) and plethysmographic functional residual capacity (FRCp) for white infants during the first 2 years of life. Methods IPFTs were measured using the Jaeger BabyBody system and standardized protocols. Reference equations, adjusted for body size, age, and sex where appropriate, were created using multilevel modeling. Results The ratio of lung function to body length changes markedly with growth, thereby precluding its use for any outcome. While the ratio of tidal volume and Crs to body weight remained relatively constant with growth, this was not the case for FRCp. Even in healthy infants, a strong inverse relationship was observed between lung function/body weight and weight z‐score which could distort interpretation of results in growth‐restricted infants with lung disease, such as cystic fibrosis. Reference equations were derived from 153 healthy white infants on 232 test occasions (median age 35.5 weeks [range: 2.6–104.7]). Crown‐heel length was the strongest predictor of IPF. Conclusions When reporting IPF, use of size‐corrected ratios should be discouraged, with interpretation instead based on appropriate reference equations. The current equations are applicable to white infants and young children up to 2 years of age, studied using the same commercially available equipment. The extent to which these equations are applicable to infants and young children of other ethnic backgrounds or who are tested with different equipment needs to be established. Pediatr Pulmonol. 2013; 48:370–380. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.22656
Titel-ID: cdi_proquest_miscellaneous_1318692153
Format
–
Schlagworte
Age Factors
,
Airway Resistance
,
Bias
,
Body Size
,
child
,
Child, Preschool
,
Female
,
Functional Residual Capacity
,
Humans
,
Infant
,
Lung - physiology
,
Lung Compliance
,
lung volumes
,
Male
,
Models, Statistical
,
Plethysmography, Whole Body
,
pulmonary function tests
,
Reference Values
,
respiratory mechanics
,
Respiratory Mechanics - physiology
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