Details

Autor(en) / Beteiligte

• Gueresi, P.
• Miglio, R.
• Monti, D.
• Mari, D.
• Sansoni, P.
• Caruso, C.
• Bonafede, E.
• Bucci, L.
• Cevenini, E.
• Ostan, R.
• Palmas, M.G.
• Pini, E.
• Scurti, M.
• Franceschi, C.

Titel

Does the longevity of one or both parents influence the health status of their offspring?

Ist Teil von

• Experimental gerontology, 2013-04, Vol.48 (4), p.395-400

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• According to the findings of some recent studies, the centenarians' offspring appear to represent a promising model for research on longevity and healthy aging. This study compares the health status and the functional status of three groups of subjects: 1. individuals with two long-lived parents (one of whom centenarian), 2. individuals with only one long-lived (centenarian) parent, and 3. individuals with no long-lived parents. The goal is to verify whether the centenarians' offspring display any advantage over the offspring of both non-long-lived parents and to evaluate whether the longevity of the non-centenarian parent provides a further advantage. A total of 374 subjects (mean age approximately 70years) was examined. A threshold for longevity was established for non-centenarian parents through demographic data available for Italy (males surviving to at least 81years of age and females to 87years). The participants were assessed for their health and functional status by means of a standardized questionnaire and tests of physical performance. Data were analyzed using multivariate regression models adjusted for socio-demographic characteristics and risk factors for age-related pathologies. The results of the study show that centenarians' offspring have a better functional status, a reduced risk for several age-related pathologies and reduced drug consumption than the offspring of non-long-lived parents. In addition, the health status of centenarians' offspring does not appear to be influenced by the longevity of the second parent. It therefore seems possible to conclude that at ages around 70years the genetic contribution to health status deriving from having one centenarian parent is not substantially improved if the other parent is also long-lived. ► In centenarians' offspring a longevity threshold was assessed for the second parent. ► Two groups of centenarians' offspring based on second parent's longevity were defined. ► Groups of centenarians' offspring and controls were compared. ► A better functional and health status characterizes the centenarians' offspring. ► Health status of centenarians' offspring is not affected by second parent's longevity.