Details

Autor(en) / Beteiligte

• Marzouk, M. S.
• Moharram, F. A.
• El Dib, R. A.
• El-Hossary, D. G.

Titel

Novel Macrocyclic Monoterpene Glycosides from Bioactive Extract of Parkinsonia aculeata L

Ist Teil von

• Cell biochemistry and biophysics, 2013-04, Vol.65 (3), p.301-313

Ort / Verlag

New York: Springer-Verlag

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Five novel macrocyclic monoterpene O -glycosides, parkinsenes A–E ( 1 – 5 ), and eleven known phenolic metabolites including three 3- O -glycosylflavonols ( 6 – 8 ), five C -glycosylflavones ( 9 – 13 ), p -hydroxybenzoic acid ( 14 ), esculetin ( 15 ), and diosmetin ( 16 ) were isolated from the leaves and small twigs of Parkinsonia aculeata L. (Fabaceae). Their structures were established by chemical and spectroscopic analyses (UV, ESI–MS, and 1D/2D NMR). The investigated 80 % aqueous methanol extract (AME) showed significant analgesic, antipyretic, anti-inflammatory, hepatoprotective, hypoglycemic, hypocholesterolemic, and antioxidant activities in a dose-dependent manner using two different doses 250 and 500 mg/kg b. wt.