Details

Autor(en) / Beteiligte

• Kohno, Mikihiro
• Shirabe, Ken
• Mano, Yohei
• Muto, Jun
• Motomura, Takashi
• Takeishi, Kazuki
• Toshima, Takeo
• Yoshimatsu, Masanori
• Ijichi, Hideki
• Harada, Noboru
• Aishima, Shinichi
• Uchiyama, Hideaki
• Yoshizumi, Tomoharu
• Taketomi, Akinobu
• Maehara, Yoshihiko

Titel

Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case

Ist Teil von

• Surgery today (Tokyo, Japan), 2013-04, Vol.43 (4), p.439-445

Ort / Verlag

Japan: Springer Japan

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.