Environmental toxicology and pharmacology, 2013-03, Vol.35 (2), p.300-310
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Effect of Bisphenol-A on insulin signal transduction and glucose oxidation in liver of adult male albino rat
- Ist Teil von
- Environmental toxicology and pharmacology, 2013-03, Vol.35 (2), p.300-310
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2013
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Highlights ► In our work, Bisphenol-A (BPA) treatment significantly decreased the glucose oxidation whereas the fasting blood glucose was unaffected, but decreased the glycogen concentration. ► BPA treatment resulted in hyperinsulinemia but decreased the serum testosterone. ► Levels of IR, Akt, and p-Akt(ser 473) proteins were impaired. ► BPA treatment significantly increased the GLUT2 mRNA as well as cytosolic and plasma membrane GLUT2 level. ► It is concluded that Bisphenol-A treatment impairs hepatic glucose oxidation through defective insulin signal transduction, but enhanced the expression of GLUT2.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1382-6689eISSN: 1872-7077DOI: 10.1016/j.etap.2012.12.016Titel-ID: cdi_proquest_miscellaneous_1315630869
- Format
- –
- Schlagworte
- Animals, Benzhydryl Compounds - toxicity, Bisphenol-A, Blood Glucose - analysis, Cell Membrane - drug effects, Cell Membrane - metabolism, Cytosol - drug effects, Cytosol - metabolism, Emergency, Endocrine disruptor, Endocrine Disruptors - toxicity, Glucose - metabolism, Glucose Transporter Type 2 - metabolism, Glycogen - metabolism, Hyperinsulinemia, Insulin - blood, Insulin - metabolism, Insulin resistance, Liver - drug effects, Liver - metabolism, Male, Oxidation-Reduction, Phenols - toxicity, Proto-Oncogene Proteins c-akt - genetics, Proto-Oncogene Proteins c-akt - metabolism, Rats, Rats, Wistar, Receptor, Insulin - genetics, Receptor, Insulin - metabolism, Signal Transduction - drug effects, Testosterone - blood, Xenoestrogen