Details

Autor(en) / Beteiligte

• Prinzen, L.
• Staal, H. M.
• Rouwette, S. J. M.
• Beckers, E. A. M.
• ten Broeke, R. H. M.
• van Rhijn, L. W.
• Henskens, Y. M. C.

Titel

Triple Red Blood Cell Alloantibody Formation After Bone‐Allograft Transplantation

Ist Teil von

• American journal of transplantation, 2013-01, Vol.13 (1), p.229-231

Ort / Verlag

Hoboken, NJ: Wiley

Erscheinungsjahr

2013

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• In this case report, we provide evidence for the possibility of red blood cell alloimmunization after bone‐allograft transplantation. Here, we present a 13‐year‐old boy who received a bone allograft due to impending hip‐luxation. Five months later he was shown to have developed three different alloantibodies: anti‐D, anti‐C and anti‐E, which were induced by the bone allograft. Red blood cell alloimmunization is a possible adverse event when a patient is exposed to allogenic red blood cells. These antibodies may cause transfusion reactions when incompatible blood is administered. More importantly, these antibodies may cause severe, or even fatal, hemolytic disease of the fetus or newborn, stretching the importance of preventing antibody formation, especially in young women. This case demonstrates the importance of selecting rhesus phenotype compatible bone allografts. A 13‐year‐old boy with no history of blood transfusions developed three different rhesus alloantibodies after receiving a bone allograft, providing evidence that primary red blood cell immunization is possible after bone allograft transplantation.