Details

Autor(en) / Beteiligte

• Li, Ling
• Wen, Juan
• Tuo, Qin-Hui
• Liao, Duan-Fang

Titel

Effects of SUMOylation on the subcellular localization and function of DAXX

Ist Teil von

• Sheng li hsüeh pao, 2013-02, Vol.65 (1), p.89-95

Ort / Verlag

China

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.