Journal of ethnopharmacology, 2013-03, Vol.146 (1), p.271-277
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Geniposidic acid protects against d-galactosamine and lipopolysaccharide-induced hepatic failure in mice
- Ist Teil von
- Journal of ethnopharmacology, 2013-03, Vol.146 (1), p.271-277
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders. This study examined the cytoprotective properties of GA against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were given an intraperitoneal injection of GA (12.5, 25, 50mg/kg) 1h before receiving GalN (800mg/kg)/LPS (40μg/kg). Liver and blood samples were collected 1 and 8h after GalN/LPS injection. The survival rate of the GA group was significantly higher than the control. GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreased hepatic glutathione content. These changes were attenuated by GA. GA augmented increases in serum interleukin-6 level, heme oxygenase-1 and NF-E2-related factor 2 protein expression. Mice treated with GA decreased cleaved caspase-8 and caspase-3 protein expression and showed significantly fewer apoptotic cells. GA increased Bcl-xL protein expression and decreased Bax protein expression. Moreover, GA treatment enhanced phosphorylation of signal transducer and activator of transcription 3. Our findings suggest that geniposidic acid alleviates GalN/LPS-induced liver injury by enhancing antioxidative defense system and reducing apoptotic signaling pathways. [Display omitted]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-8741eISSN: 1872-7573DOI: 10.1016/j.jep.2012.12.042Titel-ID: cdi_proquest_miscellaneous_1289487486
- Format
- –
- Schlagworte
- Animals, Apoptosis, Apoptosis - drug effects, bcl-2-Associated X Protein - metabolism, bcl-X Protein - metabolism, Bcl-xL, blood, caspase-3, caspase-8, Fruit, Galactosamine, Gardenia, Geniposidic acid, Glutathione - metabolism, heme oxygenase (decyclizing), Heme oxygenase-1, Heme Oxygenase-1 - metabolism, Hepatic failure, inflammation, interleukin-6, Interleukin-6 - blood, intraperitoneal injection, Iridoid Glucosides - pharmacology, Iridoid Glucosides - therapeutic use, jaundice, lipid peroxidation, Lipid Peroxidation - drug effects, Lipopolysaccharides, liver, liver failure, Liver Failure - chemically induced, Liver Failure - drug therapy, Liver Failure - metabolism, Liver Failure - pathology, Male, Membrane Proteins - metabolism, Mice, Mice, Inbred ICR, necrosis, NF-E2-Related Factor 2 - metabolism, phosphorylation, Phytotherapy, Plant Extracts - pharmacology, Plant Extracts - therapeutic use, Protective Agents - pharmacology, Protective Agents - therapeutic use, protein synthesis, Rubiaceae, STAT3, STAT3 Transcription Factor - metabolism, survival rate, tumor necrosis factor-alpha, Tumor Necrosis Factor-alpha - blood