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Neurostimulation for Parkinson's Disease with Early Motor Complications
Ist Teil von
The New England journal of medicine, 2013-02, Vol.368 (7), p.610-622
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
In this 2-year trial involving patients with Parkinson's disease and early motor complications, subthalamic stimulation plus medical therapy resulted in better quality of life and motor function than medical therapy alone.
Parkinson's disease is a progressive neurodegenerative disease that affects dopaminergic neurotransmission, resulting in bradykinesia, rigidity, and rest tremor. After an initial honeymoon period, during which there is a sustained response to dopaminergic treatment, beneficial effects are hampered by levodopa-induced motor complications,
1
progressively compromising quality of life.
2
–
4
Because levodopa-responsive parkinsonian symptoms are improved by high-frequency stimulation of the subthalamic nucleus,
5
,
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neurostimulation has become an established treatment for advanced Parkinson's disease with medically intractable fluctuations and dyskinesia
7
–
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and has shown long-term efficacy.
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–
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It is typically used after the disease has been present for 11 to 13 years,
7
– . . .