Details

Autor(en) / Beteiligte

• Yu, Y-H
• Chen, H-A
• Chen, P-S
• Cheng, Y-J
• Hsu, W-H
• Chang, Y-W
• Chen, Y-H
• Jan, Y
• Hsiao, M
• Chang, T-Y
• Liu, Y-H
• Jeng, Y-M
• Wu, C-H
• Huang, M-T
• Su, Y-H
• Hung, M-C
• Chien, M-H
• Chen, C-Y
• Kuo, M-L
• Su, J-L

Titel

MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol

Ist Teil von

• Oncogene, 2013-01, Vol.32 (4), p.431-443

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol-∣miRNA-520h-∣PP2A/C-∣Akt → NF-κB → FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression.