Organic letters, 2012-12, Vol.14 (24), p.6310-6313
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines
- Ist Teil von
- Organic letters, 2012-12, Vol.14 (24), p.6310-6313
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The first total synthesis of the marine natural products Psammaplin C and Tokaradine A is described. Benzylidene rhodanines were utilized as versatile intermediates toward the synthesis of seven brominated marine sponge metabolites through the optimization of protection group strategies. Spermatinamine demonstrated good inhibition of all cancer cell lines tested, in particular the leukemia K562 and colon cancer HT29 cell lines.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1523-7060eISSN: 1523-7052DOI: 10.1021/ol303057aTitel-ID: cdi_proquest_miscellaneous_1284628057
- Format
- –
- Schlagworte
- Animals, Benzylidene Compounds - chemical synthesis, Benzylidene Compounds - chemistry, Benzylidene Compounds - pharmacology, Drug Screening Assays, Antitumor, HT29 Cells, Humans, Hydrocarbons, Brominated - chemical synthesis, Hydrocarbons, Brominated - chemistry, Hydrocarbons, Brominated - pharmacology, Marine Biology, Molecular Structure, Porifera - chemistry, Rhodanine - analogs & derivatives, Rhodanine - chemical synthesis, Rhodanine - chemistry, Rhodanine - pharmacology, Spermine - analogs & derivatives, Spermine - pharmacology, Sulfones - chemical synthesis, Sulfones - chemistry, Sulfones - pharmacology, Tyrosine - analogs & derivatives, Tyrosine - pharmacology