Details

Autor(en) / Beteiligte

• Aggarwal, Varinder K
• Ball, Liam T
• Carobene, Simon
• Connelly, Rickki L
• Hesse, Matthew J
• Partridge, Benjamin M
• Roth, Philippe
• Thomas, Stephen P
• Webster, Matthew P

Titel

Application of the lithiation-borylation reaction to the rapid and enantioselective synthesis of the bisabolane family of sesquiterpenes

Ist Teil von

• Chemical communications (Cambridge, England), 2012-01, Vol.48 (74), p.9230-9232

Ort / Verlag

England

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The expedient enantioselective synthesis of 5 bisabolane sesquiterpenes has been achieved using a common, one-pot lithiation-borylation reaction of secondary benzylic carbamates and either protodeboronation or oxidation to give the natural products in fewer than 5 steps, with high yield and >94 : 6 er.