Details

Autor(en) / Beteiligte

• Obembe, A.O.
• Antai, A.B.
• Owu, D.U.
• Okwari, O.O.
• Eteng, M.U.
• Osim, E.E.

Titel

Bile secretion and palm oil diets in Wistar rats

Ist Teil von

• Nutrition and food science, 2010-01, Vol.40 (4), p.388-394

Ort / Verlag

Bradford: Emerald Group Publishing Limited

Erscheinungsjahr

2010

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose - Chronic feeding with thermoxidized palm oil causes tissue damage. The purpose of this paper is to ascertain whether chronic feeding of oxidized and fresh palm oil affects biliary secretion.Design methodology approach - Albino Wistar rats were divided into three groups of ten rats each. The first group was the control and were fed on normal rat chow, while the second (FPO) and third group (TPO) were fed diet containing either fresh or thermoxidized palm oil (15per cent (w w)) for 14 weeks. Biliary secretion, bilirubin, electrolytes, cholesterol and serum levels of alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase enzymes were measured.Findings - Biliary secretion in TPO was significantly (p < 0.05) lower compared with the control or FPO. Electrolytes (Na+, Cl− and HCO3−) content of bile were significantly (p < 0.05) lower in TPO compared with control or FPO group. Conjugated and un-conjugated bilirubin levels were significantly (p < 0.05) elevated in TPO compared with control or FPO. The levels of serum liver enzymes were significantly (p < 0.001) higher in TPO than control or FPO. The cholesterol level in the TPO was significantly higher (p < 0.001) than in control or FPO.Research limitations implications - The non-clinical approach and use of experimental animals present limitations to the study.Originality value - These results suggest that long-term feeding of thermally oxidized palm oil alters bile composition and decreases biliary flow due to its hazardous free radicals.