Neuroscience, 2013-02, Vol.231, p.206-215
2013
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- Autor(en) / Beteiligte
- Titel
- Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity
- Ist Teil von
- Neuroscience, 2013-02, Vol.231, p.206-215
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Highlights ► High K+ depolarization protects dopaminergic neurons from MPP+ cytotoxicity. ► The protective effect is dependent on nitric oxide and protein kinase G (PKG). ► 8-Nitro-cGMP is produced in response to high K+ depolarization. ► 8-Nitro-cGMP confers neuroprotection in a PKG-dependent manner. ► PKG-independent expression of heme oxygenase-1 is also involved in neuroprotection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.11.044Titel-ID: cdi_proquest_miscellaneous_1282840008
- Format
- –
- Schlagworte
- 1-Methyl-4-phenylpyridinium - pharmacology, Animals, Biological and medical sciences, cyclic GMP, Cyclic GMP - analogs & derivatives, Cyclic GMP - pharmacology, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, dopamine neurons, Dopaminergic Neurons - drug effects, Dopaminergic Neurons - metabolism, Enzyme Inhibitors - pharmacology, Guanylate Cyclase - metabolism, heme oxygenase-1, Medical sciences, Mesencephalon - metabolism, Neurology, neuronal activity, neuroprotection, NG-Nitroarginine Methyl Ester - pharmacology, nitric oxide, Nitric Oxide - metabolism, Nitric Oxide Donors - pharmacology, Rats, Receptors, Cytoplasmic and Nuclear - metabolism, Signal Transduction - drug effects, Signal Transduction - physiology, Soluble Guanylyl Cyclase, Thionucleotides - pharmacology