Neuroscience, 2013-02, Vol.231, p.233-246
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin
- Ist Teil von
- Neuroscience, 2013-02, Vol.231, p.233-246
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► The serine protease subtilisin induced hippocampal LTD with a non-classical modification of caspase-3 and caspase-9. ► Late subtilisin LTD is reduced by the proteasome inhibitor MG132. ► Proteasomal inhibition reduces immediate LTP but increases late LTP and promotes LTP saturation. ► Proteasomal activity contributes to late subtilisin LTD and normal LTP.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.11.029Titel-ID: cdi_proquest_miscellaneous_1282835225
- Format
- –
- Schlagworte
- Amino Acid Chloromethyl Ketones - pharmacology, Animals, Biological and medical sciences, Caspase 3 - metabolism, Caspase 9 - metabolism, Caspase Inhibitors - pharmacology, caspase-3, Central nervous system, Cysteine Proteinase Inhibitors - pharmacology, Dose-Response Relationship, Drug, Electrophysiology, Excitatory Postsynaptic Potentials - drug effects, Excitatory Postsynaptic Potentials - physiology, Fundamental and applied biological sciences. Psychology, Hippocampus - drug effects, Hippocampus - physiology, Leupeptins - pharmacology, long-term depression, Long-Term Potentiation - drug effects, Long-Term Potentiation - physiology, Long-Term Synaptic Depression - drug effects, Long-Term Synaptic Depression - physiology, LTD, Male, Neurology, Phosphorylation - drug effects, proteasome, Proteasome Endopeptidase Complex - drug effects, Proteasome Endopeptidase Complex - metabolism, Rats, Rats, Wistar, Signal Transduction - drug effects, subtilisin, Subtilisins - pharmacology, synaptic plasticity, Vertebrates: nervous system and sense organs