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Moderately high intake of folic acid has a negative impact on mouse embryonic development
Birth defects research. A Clinical and molecular teratology, 2013-01, Vol.97 (1), p.47-52
Mikael, Leonie G.
Deng, Liyuan
Paul, Ligi
Selhub, Jacob
Rozen, Rima
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Mikael, Leonie G.
Deng, Liyuan
Paul, Ligi
Selhub, Jacob
Rozen, Rima
Titel
Moderately high intake of folic acid has a negative impact on mouse embryonic development
Ist Teil von
Birth defects research. A Clinical and molecular teratology, 2013-01, Vol.97 (1), p.47-52
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
BACKGROUND The incidence of neural tube defects has diminished considerably since the implementation of food fortification with folic acid (FA). However, the impact of excess FA intake, particularly during pregnancy, requires investigation. In a recent study, we reported that a diet supplemented with 20‐fold higher FA than the recommended intake for rodents had adverse effects on embryonic mouse development at embryonic days (E)10.5 and 14.5. In this report, we examined developmental outcomes in E14.5 embryos after administering a diet supplemented with 10‐fold higher FA than recommended to pregnant mice with and without a mild deficiency of methylenetetrahydrofolate reductase (MTHFR). METHODS Pregnant mice with or without a deficiency in MTHFR were fed a control diet (recommended FA intake of 2 mg/kg diet for rodents) or an FA‐supplemented diet (FASD; 10‐fold higher than the recommended intake [20 mg/kg diet]). At E14.5, mice were examined for embryonic loss and growth retardation, and hearts were assessed for defects and for ventricular wall thickness. RESULTS Maternal FA supplementation was associated with embryonic loss, embryonic delays, a higher incidence of ventricular septal defects, and thinner left and right ventricular walls, compared to mothers fed control diet. CONCLUSIONS Our work suggests that even moderately high levels of FA supplementation may adversely affect fetal mouse development. Additional studies are warranted to evaluate the impact of high folate intake in pregnant women. Birth Defects Research (Part A), 2013. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1542-0752
eISSN: 1542-0760
DOI: 10.1002/bdra.23092
Titel-ID: cdi_proquest_miscellaneous_1273433947
Format
–
Schlagworte
Animals
,
Biological and medical sciences
,
Cardiology. Vascular system
,
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
,
developmental delay
,
Dose-Response Relationship, Drug
,
Drug toxicity and drugs side effects treatment
,
Embryo Loss - chemically induced
,
Embryo, Mammalian - drug effects
,
Embryology: invertebrates and vertebrates. Teratology
,
Embryonic Development - drug effects
,
Female
,
Folic Acid - toxicity
,
Fundamental and applied biological sciences. Psychology
,
Heart
,
Heart - drug effects
,
Heart - embryology
,
heart defects
,
Heart Septal Defects, Ventricular - chemically induced
,
Heart Ventricles - drug effects
,
Heart Ventricles - embryology
,
high folate
,
Male
,
Medical sciences
,
Methylenetetrahydrofolate Reductase (NADPH2) - blood
,
Methylenetetrahydrofolate Reductase (NADPH2) - deficiency
,
Mice
,
Mice, Inbred BALB C
,
Miscellaneous (drug allergy, mutagens, teratogens...)
,
MTHFR
,
Pharmacology. Drug treatments
,
Pregnancy
,
Teratology. Teratogens
,
ventricular septal defects
,
Vitamin B Complex - toxicity
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