Zhong hua yi xue za zhi, 2012-08, Vol.92 (29), p.2075-2077
2012
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- Autor(en) / Beteiligte
- Titel
- Effects of tetramethylpyrazine on nitric oxide synthase activity and calcium ion concentration of skeletal muscle in hindlimb unloading rats
- Ist Teil von
- Zhong hua yi xue za zhi, 2012-08, Vol.92 (29), p.2075-2077
- Ort / Verlag
- China
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To explore the effects of tetramethylpyrazine on the nitric oxide synthase activity and calcium ion concentration in skeletal muscle fiber and decipher the possible mechanisms of anti-muscle atrophy function of tetramethylpyrazine in hindlimb unloading rats. Hindlimb unloading (HLU) rats were used as a muscle atrophy model to study the activity of nitric oxide synthase by colorimetry. The concentration of intracellular calcium ion was measured by laser scanning confocal microscope. A total of 18 female rats were randomly divided into 3 groups: control (CON), hindlimb unloading with water (HLU + W) and hindlimb unloading with tetramethylpyrazine (HLU + Tmp) (n = 6 each). (1) Compared with CON, the activity of nitric oxide synthase decreased by 28% in HLU + W (P < 0.05) and decreased by 46% in HLU + Tmp (P < 0.01). The activity of nitric oxide synthase less decreased in HLU + Tmp than that in HLU + W, but it was not statistically significant (P > 0.05). (2) Compared with CON, the concentrations of intracellular
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0376-2491Titel-ID: cdi_proquest_miscellaneous_1273282282
- Format
- –
- Schlagworte
- Animals, Calcium - analysis, Female, Muscle Fibers, Skeletal - metabolism, Muscle, Skeletal - drug effects, Muscle, Skeletal - metabolism, Muscle, Skeletal - physiopathology, Muscular Atrophy - metabolism, Muscular Atrophy - physiopathology, Muscular Disorders, Atrophic - metabolism, Muscular Disorders, Atrophic - physiopathology, Nitric Oxide Synthase - metabolism, Pyrazines - pharmacology, Rats, Rats, Sprague-Dawley