AIDS (London), 2012-11, Vol.26 (18), p.2337-2344
2012
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- Autor(en) / Beteiligte
- Titel
- The influence of HLA supertype on thymidine analogue associated with low peripheral fat in HIV
- Ist Teil von
- AIDS (London), 2012-11, Vol.26 (18), p.2337-2344
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To examine the relationship between human leukocyte antigen (HLA) genotype and body composition changes induced by thymidine analogue nucleoside reverse transcriptase inhibitor (NtRTI) use in HIV-positive individuals. Data collected during the Simplification with Tenofovir-Emtricitabine (TDF-FTC) or Abacavir-Lamivudine (ABC-3TC) (STEAL) study were analysed to examine the potential association of HLA genotypes with changes in body composition in treatment-experienced HIV-positive individuals. Demographic, HIV-related, body composition and HLA genotyping data from the STEAL study were used in this analysis. The mean percentage peripheral fat at study baseline was compared in participants with and without prior NtRTI use. Analyses were also carried out for each HLA supertype strata, for five HLA genes, within the thymidine-exposed group. These comparisons were made using Mann-Whitney rank-sum tests. Participants with prior NtRTI use had a significantly lower baseline mean peripheral fat percentage compared to those without NtRTI use (31.9 vs. 34.7%; P = 0.0045). However, participants carrying one or more of the three particular HLA supertype alleles, A01, B08 and DQ2, showed no significant difference in mean peripheral fat percentage at baseline by NtRTI use. Among participants with prior NtRTI exposure, there were significant differences in mean peripheral fat by HLA A01, B08 and DQ2 allele expression compared to those without expression of these alleles (A01: 34.91% vs. no A01: 30.3%; P = 0.0087; B08: 36.2% vs. no B08: 31.1%; P = 0.0317; DQ2: 35.16% vs. no DQ2: 30.06%; P = 0.0081). This analysis suggests that HIV-infected individuals carrying HLA A01, B08 or DQ2 supertype alleles may be resistant to NtRTI-induced peripheral fat loss.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0269-9370eISSN: 1473-5571DOI: 10.1097/QAD.0b013e32835ab213Titel-ID: cdi_proquest_miscellaneous_1273252696
- Format
- –
- Schlagworte
- Adenine - analogs & derivatives, Adenine - pharmacology, AIDS/HIV, Anti-HIV Agents - pharmacology, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antiviral agents, Australia, Biological and medical sciences, Biomarkers - metabolism, Blood Glucose, Body composition, Body Fat Distribution, CD4 Lymphocyte Count, Data processing, Demography, Deoxycytidine - analogs & derivatives, Deoxycytidine - pharmacology, Dideoxynucleosides - pharmacology, Drug Combinations, Drug Resistance, Viral, Drug toxicity and drugs side effects treatment, Emtricitabine, Female, Genotype, Genotypes, Genotyping, Histocompatibility antigen HLA, HIV Infections - drug therapy, HIV Infections - genetics, HIV Infections - metabolism, HIV-Associated Lipodystrophy Syndrome - drug therapy, HIV-Associated Lipodystrophy Syndrome - genetics, HIV-Associated Lipodystrophy Syndrome - metabolism, HLA Antigens - drug effects, HLA Antigens - metabolism, HLA-A1 Antigen - metabolism, HLA-B8 Antigen - metabolism, HLA-DQ Antigens - metabolism, Human immunodeficiency virus, Human viral diseases, Humans, Infectious diseases, Lamivudine - pharmacology, Linkage Disequilibrium, Male, Medical sciences, Middle Aged, Miscellaneous (drug allergy, mutagens, teratogens...), Multicenter Studies as Topic, nucleoside analogs, nucleoside reverse transcriptase inhibitors, Organophosphonates - pharmacology, Pharmacology. Drug treatments, Predictive Value of Tests, Randomized Controlled Trials as Topic, Tenofovir, Thymidine, Thymidine - analogs & derivatives, Thymidine - metabolism, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids