Details

Autor(en) / Beteiligte

• Xie, Hexin
• Song, Aiguo
• Zhang, Xinshuai
• Chen, Xiaobei
• Li, Hao
• Sheng, Chunquan
• Wang, Wei

Titel

Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Ist Teil von

• Chemical communications (Cambridge, England), 2013-01, Vol.49 (9), p.928-930

Ort / Verlag

England

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.