Details

Autor(en) / Beteiligte

• Wüthrich, Rudolf P
• Mei, Changlin

Titel

Aquaretic Treatment in Polycystic Kidney Disease

Ist Teil von

• The New England journal of medicine, 2012-12, Vol.367 (25), p.2440-2442

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Autosomal dominant polycystic kidney disease (ADPKD), the most common hereditary kidney disease, progresses relentlessly to end-stage kidney disease before the age of 60 years in half the affected patients. One in 10 patients undergoing dialysis has ADPKD. The disease is characterized by prominent cystic enlargement of the kidneys, which is often associated with episodes of pain, hematuria, and cyst infection. An effective therapy to slow the progression of this disease does not exist, although several promising drug candidates are being tested. 1 Vasopressin-mediated cyclic AMP (cAMP) generation is enhanced in polycystic kidneys, driving the proliferation of cyst epithelial cells and the . . .