Details

Autor(en) / Beteiligte

• Kelly, Catherine M
• Bernard, Philip S
• Krishnamurthy, Savitri
• Wang, Bailiang
• Ebbert, Mark TW
• Bastien, Roy RL
• Boucher, Kenneth M
• Young, Elliana
• Iwamoto, Takayuki
• Pusztai, Lajos

Titel

Agreement in Risk Prediction Between the 21-Gene Recurrence Score Assay (Oncotype DX registered ) and the PAM50 Breast Cancer Intrinsic Classifier registered in Early-Stage Estrogen Receptor-Positive Breast Cancer

Ist Teil von

• The oncologist (Dayton, Ohio), 2012-01, Vol.17 (4), p.492-498

Erscheinungsjahr

2012

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• PURPOSE: To compare risk assignment by PAM50 Breast Cancer Intrinsic Classifier registered and Oncotype DX_Recurrence Score (RS) in the same population. METHODS: RNA was extracted from 151 estrogen receptor (ER)+ stage I-II breast cancers and gene expression profiled using PAM50 "intrinsic" subtyping test. RESULTS: One hundred eight cases had complete molecular information; 103 (95%) were classified as luminal A (n = 76) or luminal B (n = 27). Ninety-two percent (n = 98) had a low (n = 59) or intermediate (n = 39) RS. Among luminal A cancers, 70% had low (n = 53) and the remainder (n = 23) had an intermediate RS. Among luminal B cancers, nine were high (33%) and 13 were intermediate (48%) by the RS. Almost all cancers with a high RS were classified as luminal B (90%, n = 9). One high RS cancer was identified as basal-like and had low ER/ESR1 and low human epidermal growth factor receptor 2 (HER2) expression by quantitative polymerase chain reaction in both assays. The majority of low RS cases were luminal A (83%, n = 53). Importantly, half of the intermediate RS cancers were re-categorized as low risk luminal A subtype by PAM50. CONCLUSION: There is good agreement between the two assays for high (i.e., luminal B or RS > 31) and low (i.e., luminal B or RS < 18) prognostic risk assignment but PAM50 assigns more patients to the low risk category. About half of the intermediate RS group was reclassified as luminal A by PAM50.