Neuroscience, 2013-01, Vol.228, p.36-46
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: A role for hippocampal cell proliferation
- Ist Teil von
- Neuroscience, 2013-01, Vol.228, p.36-46
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► BALB/cOLaHsd mice do not respond to chronic desipramine treatment in the NIH. ► Addition of lithium to desipramine induced antidepressant-like behaviour in the NIH. ► Lithium plus desipramine but neither drug alone increased hippocampal cell proliferation. ► Hippocampal neurogenesis may contribute to lithium augmentation of antidepressants.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.09.072Titel-ID: cdi_proquest_miscellaneous_1240901513
- Format
- –
- Schlagworte
- Animals, antidepressant, augmentation, behaviour, Biological and medical sciences, Cell Proliferation - drug effects, Depressive Disorder, Treatment-Resistant - drug therapy, Depressive Disorder, Treatment-Resistant - pathology, Depressive Disorder, Treatment-Resistant - psychology, Desipramine - administration & dosage, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, hippocampal neurogenesis, Hippocampus - cytology, Hippocampus - drug effects, Hippocampus - physiology, lithium, Lithium Carbonate - administration & dosage, Male, Medical sciences, Mice, Mice, Inbred BALB C, Neurology, Neuropharmacology, Pharmacology. Drug treatments, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Treatment Outcome, treatment-resistant depression