Details

Autor(en) / Beteiligte

• Tejedor, David
• Méndez-Abt, Gabriela
• Cotos, Leandro
• García-Tellado, Fernando

Titel

Propargyl Claisen rearrangement: allene synthesis and beyond

Ist Teil von

• Chemical Society reviews, 2013-01, Vol.42 (2), p.458-471

Ort / Verlag

England

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The propargyl Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-sigmatropic transformation of propargyl vinyl ethers. The correct use of appropriate propargyl vinyl ethers as starting materials coupled with suitable reaction conditions can aid in the development of new domino methodologies in which the allenes are valuable intermediates in route to a wide range of important classes of organic compounds. This tutorial review focuses on the use of propargyl vinyl ethers towards the synthesis of functionalized allenes via the propargyl Claisen rearrangement and highlights the development of new allene-based domino methodologies.