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Putative tumor suppressor miR‐145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 gene
Cancer, 2011-01, Vol.117 (1), p.86-95
Zhang, Jianjun
Guo, Haiyan
Zhang, He
Wang, Haibo
Qian, Guanxiang
Fan, Xianqun
Hoffman, Andrew R.
Hu, Ji‐Fan
Ge, Shengfang
2011
Details
Autor(en) / Beteiligte
Zhang, Jianjun
Guo, Haiyan
Zhang, He
Wang, Haibo
Qian, Guanxiang
Fan, Xianqun
Hoffman, Andrew R.
Hu, Ji‐Fan
Ge, Shengfang
Titel
Putative tumor suppressor miR‐145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 gene
Ist Teil von
Cancer, 2011-01, Vol.117 (1), p.86-95
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND: Tumor suppressor microRNA miR‐145 is commonly down‐regulated in colon carcinoma tissues, but its specific role in tumors remains unknown. METHODS: In this study, the authors identified the Friend leukemia virus integration 1 gene (FLI1) as a novel target of miR‐145. FLI1 is involved in t(11;22)(q24:q12) reciprocal chromosomal translocation in Ewing sarcoma, and its expression appears to be associated with biologically more aggressive tumors. RESULTS: The authors demonstrated that miR‐145 targets a putative microRNA regulatory element in the 3′‐untranslated region (UTR) of FLI1, and its abundance is reversely associated with FLI1 expression in colon cancer tissues and cell lines. By using a luciferase/FLI1 3′‐UTR reporter system, they found that miR‐145 down‐regulated the reporter activity, and this down‐regulation was reversed by anti–miR‐145. Mutation of the miR‐145 microRNA regulatory element sequence in the FLI1 3′‐UTR abolished the activity of miR‐145. miR‐145 decreased FLI1 protein but not FLI1 mRNA, suggesting a mechanism of translational regulation. Furthermore, the authors demonstrated that miR‐145 inhibited cell proliferation and sensitized LS174T cells to 5‐fluorouracil–induced apoptosis. CONCLUSIONS: Taken together, these results suggest that miR‐145 functions as a tumor suppressor by down‐regulating oncogenic FLI1 in colon cancer. Cancer 2011. © 2010 American Cancer Society. The authors identified FLI1, a gene involved in t(11;22)(q24:q12) reciprocal chromosomal translocation in Ewing sarcoma, as a novel target of miR‐145, suggesting that miR‐145 functions as a tumor suppressor by down‐regulating oncogenic FLI1 in colon cancer.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X, 1097-0142
eISSN: 1097-0142
DOI: 10.1002/cncr.25522
Titel-ID: cdi_proquest_miscellaneous_1238120793
Format
–
Schlagworte
3' Untranslated Regions
,
Apoptosis
,
Biological and medical sciences
,
Cell Line, Tumor
,
Cell Proliferation
,
Chromosome translocations
,
Colon cancer
,
Colonic Neoplasms - genetics
,
Colonic Neoplasms - pathology
,
Computational Biology
,
Ewing's sarcoma
,
FLI1
,
FLI1 protein
,
Gastroenterology. Liver. Pancreas. Abdomen
,
Gene Expression Regulation
,
Gene Targeting
,
Genes, Tumor Suppressor
,
Humans
,
Integration
,
Medical sciences
,
microRNA
,
MicroRNAs - pharmacology
,
miRNA
,
miR‐145
,
mRNA
,
Mutation
,
Oncogenes
,
Protein Biosynthesis
,
Proto-Oncogene Protein c-fli-1 - genetics
,
Proto-Oncogene Protein c-fli-1 - metabolism
,
Regulatory sequences
,
Regulatory Sequences, Nucleic Acid
,
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
,
Translation
,
Tumor cell lines
,
tumor suppressor
,
Tumor suppressor genes
,
Tumors
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