Details

Autor(en) / Beteiligte

• Auriemma, Giulia
• Mencherini, Teresa
• Russo, Paola
• Stigliani, Mariateresa
• Aquino, Rita P.
• Del Gaudio, Pasquale

Titel

Prilling for the development of multi-particulate colon drug delivery systems: Pectin vs. pectin–alginate beads

Ist Teil von

• Carbohydrate polymers, 2013-01, Vol.92 (1), p.367-373

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• ► Colon targeted dextran beads are prepared by prilling and an enteric coating. ► Optimization of process parameters may control beads properties. ► Strength of the Zn–pectinate matrix allows to reduce the thickness of the coating. ► Piroxicam loaded multi-particulate systems show a prolonged drug release in IF. ► Such platforms may be proposed for the treatment of inflammatory bowel diseases. This paper proposes a multi-particulate drug delivery system produced by prilling technique in combination with an enteric coating. Optimization of process parameters, such as feed viscosity at nozzle, selection of cross-linker, pH of the gelling solution and cross-linking time, allows to obtain beads with strong gelled matrix. Results showed that dextran/piroxicam beads demonstrated high encapsulation efficiency, very narrow dimensional distribution and high sphericity. Coated beads retained shape and narrow size distribution of the uncoated particles. Moreover, the strength of the produced Zn2+–pectinate beads allows to reduce Eudragit® coating thickness. Piroxicam loaded multi-particulate systems show an interesting prolonged drug release in intestinal fluids. Hence, such platforms could be proposed for the treatment of inflammatory bowel diseases.