Details

Autor(en) / Beteiligte

• Fichna, J.
• Mokrowiecka, A.
• Cygankiewicz, A. I.
• Zakrzewski, P. K.
• Małecka-Panas, E.
• Janecka, A.
• Krajewska, W. M.
• Storr, M. A.

Titel

Transient Receptor Potential Vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?

Ist Teil von

• Neurogastroenterology and motility, 2012-11, Vol.24 (11), p.e557-e560

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Wiley Online Library Journals【キャンパス外アクセス可】

Beschreibungen/Notizen

• Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro‐inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up‐regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6‐trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti‐inflammatory treatment in patients with IBD.