Details

Autor(en) / Beteiligte

• CHRISTESEN, HENRIK T.
• FALKENBERG, TINE
• LAMONT, RONALD F.
• JØRGENSEN, JAN S.

Titel

The impact of vitamin D on pregnancy: a systematic review

Ist Teil von

• Acta obstetricia et gynecologica Scandinavica, 2012-12, Vol.91 (12), p.1357-1367

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Hypovitaminosis D is common in pregnancy. To systematically review the evidence on vitamin D‐dependent pregnancy outcomes, PubMed and Embase were searched for randomized control trials, cohort and case–control studies. In randomized control trials (n = 7), larger doses of vitamin D resulted in higher 25‐hydroxylated vitamin D (25OHD) levels (n = 6), increased maternal weight gain (n = 1), and fewer classical vitamin D deficiency symptoms (n = 1). In observational studies (n = 32), lower vitamin D intake, or low 25OHD‐levels, were associated with adverse fertility parameters (n = 2), preeclampsia (n = 5), gestational diabetes or higher blood glucose (n = 6), bacterial vaginosis (n = 4), primary cesarean section (n = 1), none (n = 3) or a few days’ (n = 2) shorter gestation, and postpartum depression (n = 1). Studies with few participants having low 25OHD did not identify an association to preeclampsia (n = 5) or gestational diabetes (n = 2). Increased odds of pregnancy‐associated breast cancer with 25OHD >25.8 nmol/L were observed (n = 1). In conclusion, an effect of vitamin D on several pregnancy outcomes is suggested.