Details

Autor(en) / Beteiligte

• Ribera, Josep-María
• García, Olga
• Montesinos, Pau
• Brunet, Salut
• Abella, Eugenia
• Barrios, Manuel
• González-Campos, José
• Bravo, Pilar
• Amigo, Maria-Luz
• Hernández-Rivas, Jesús-María

Titel

Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation

Ist Teil von

• British journal of haematology, 2012-10, Vol.159 (1), p.78-81

Ort / Verlag

Oxford: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Summary The main outcomes of the Programa Español para Tratamiento de Hemopatías (PETHEMA)‐acute lymphoblastic leukaemia (ALL)‐Ph‐08 trial were described and compared with those of the historical PETHEMA‐CSTIBES02 trial. The trials differed in imatinib dose (600 vs. 400 mg/d) and amount of chemotherapy (one vs. two consolidation cycles) before stem cell transplantation (SCT). All patients (n = 29) enrolled in the ALL‐Ph‐08 trial achieved complete remission (CR) (vs. 90% in CSTIBES02), and SCT was performed in CR in 90% (vs. 78%). The reduction in early death, relapse before SCT and transplant‐related mortality observed in the ALL‐Ph‐08 trial resulted in an improved 2‐year event‐free survival (63% vs. 37%, P = 0·009).