Details

Autor(en) / Beteiligte

• Coelho, Isabela
• Casare, Fernando
• Pequito, Danielle C. T.
• Borghetti, Gina
• Yamazaki, Ricardo K.
• Brito, Gleisson A. P.
• Kryczyk, Marcelo
• Fernandes, Luiz Claudio
• Coimbra, Terezila M.
• Fernandez, Ricardo

Titel

Fish Oil Supplementation Reduces Cachexia and Tumor Growth While Improving Renal Function in Tumor-Bearing Rats

Ist Teil von

• Lipids, 2012-11, Vol.47 (11), p.1031-1041

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of the present work was to study the renal function of healthy and tumor-bearing rats chronically supplemented with fish oil (FO), a source of n-3 polyunsaturated fatty acids. Weanling male rats were divided in two groups, one control (C) and another orally supplemented for 70 days with FO (1 g/kg body weight). After this time, half the animals of each group were injected in the right flank with a suspension of Walker 256 tumor cells (W and WFO). The W group had less proteinemia reflecting cachectic proteolysis, FO reversed this fact. Tumor weight gain was also reduced in WFO. Glomerular filtration rate (GFR) was not different in FO or W compared to C, but was higher in WFO. Renal plasma flow (RPF) was higher in the FO supplemented groups. The W group had lower plasma osmolality than the C group, but FO supplementation resulted in normalization of this parameter. Fractional sodium excretion (FE Na+ ) of FO rats was similar to C. Proximal Na + reabsorption, evaluated by lithium clearance, was similar among the groups. Urinary thromboxane B 2 (TXB 2 ) excretion was lower in the supplemented groups. The number of macrophages in renal tissue was higher in W compared to C rats, but was lower in WFO rats compared to W rats. In conclusion, FO supplementation resulted in less tumor growth and cachexia, and appeared to be renoprotective, as suggested by higher RPF and GFR.