Details

Autor(en) / Beteiligte

• Liu, Wenlong, MD
• Xia, Wentong, MD
• Fan, Yunping, PhD
• Wang, Hongtian, MD
• Zuo, Kejun, PhD
• Lai, Yinyan, PhD
• Li, Huabin, MD, PhD
• Liu, Zheng, MD, PhD
• Shi, Jianbo, MD, PhD
• Xu, Geng, MD, PhD

Titel

Elevated serum osteopontin level is associated with blood eosinophilia and asthma comorbidity in patients with allergic rhinitis

Ist Teil von

• Journal of allergy and clinical immunology, 2012-12, Vol.130 (6), p.1416-1418.e6

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The detection limit for OPN, IL-5, and ECP was 312.5 pg/mL, 3.9 pg/mL, and 2.0 ng/mL, respectively. [...]EOS number in venous blood was measured and counted with a standard automated cell counter. In agreement with OPN production, blood EOS number and serum ECP and IL-5 levels in the asthma+ group were significantly higher than those in the asthma- group (P < .05) (Fig 1, E, F, and G). [...]our finding provided the clue that elevated serum OPN level in patients with AR might contribute to asthma comorbidity through promoting systemic response initiated by EOS migration and activation.