Details

Autor(en) / Beteiligte

• Antal, Maria Cristina
• Petit-Demoulière, Benoît
• Meziane, Hamid
• Chambon, Pierre
• Krust, Andrée

Titel

Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (48), p.19822-19827

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• We previously generated and characterized a genuine estrogen receptor (ER) β-null mouse line (named ERβ STᴸ⁻/ᴸ⁻) and showed that ERβ STᴸ⁻/ᴸ⁻ mice were sterile, due to an ovulation impairment in females and to an unknown reason in males, as their reproductive organs and spermatozoid motility appeared normal. We report here an assessment of the sexual behavior of ERβ STᴸ⁻/ᴸ⁻ null mice. We found that ERβ STᴸ⁻/ᴸ⁻ males display mildly impaired sexual behavior and that ERβ STᴸ⁻/ᴸ⁻ females are significantly less receptive and less attractive than wild-type (WT) females. Decreased attractivity is also exhibited by ERβAF2 ⁰ but not by ERβAF1 ⁰ mutant females (females devoid of either AF2 or AF1 activation function of ERβ). Interestingly, by using an odor preference test, we have determined that the low attractiveness of ERβ STᴸ⁻/ᴸ⁻ and ERβAF2 ⁰ females is related to a deficiency of a volatile chemosignal.