Details

Autor(en) / Beteiligte

• Brighton, Timothy A
• Eikelboom, John W
• Mann, Kristy
• Mister, Rebecca
• Gallus, Alexander
• Ockelford, Paul
• Gibbs, Harry
• Hague, Wendy
• Xavier, Denis
• Diaz, Rafael
• Kirby, Adrienne
• Simes, John

Titel

Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism

Ist Teil von

• The New England journal of medicine, 2012-11, Vol.367 (21), p.1979-1987

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Low-Dose Aspirin and Recurrent Thromboembolism Results from the ASPIRE trial add evidence supporting the use of low-dose daily aspirin for preventing recurrent venous thromboembolism in patients who have had an initial unprovoked clotting episode. Patients who have had a first episode of unprovoked venous thromboembolism are at high risk for recurrence after anticoagulant therapy is discontinued. 1 – 4 Long-term treatment with a vitamin K antagonist is very effective in preventing a recurrence of venous thromboembolism while treatment continues 5 but has not been shown to improve survival, is associated with a substantially increased risk of bleeding, and is inconvenient for patients. 6 – 10 Consequently, many patients who have had a first episode of unprovoked venous thromboembolism discontinue anticoagulant therapy after 3 to 6 months despite recommendations to prolong therapy. 5 Low-dose aspirin is a simple, inexpensive, and widely . . .