Details

Autor(en) / Beteiligte

• Myburgh, John A
• Finfer, Simon
• Bellomo, Rinaldo
• Billot, Laurent
• Cass, Alan
• Gattas, David
• Glass, Parisa
• Lipman, Jeffrey
• Liu, Bette
• McArthur, Colin
• McGuinness, Shay
• Rajbhandari, Dorrilyn
• Taylor, Colman B
• Webb, Steven A.R

Titel

Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care

Ist Teil von

• The New England journal of medicine, 2012-11, Vol.367 (20), p.1901-1911

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In a study of fluid resuscitation, patients received 6% hydroxyethyl starch (HES; 130/0.4) or saline until ICU discharge or death or for 90 days. There was no significant difference in 90-day mortality, although more patients in the HES group received renal-replacement therapy. The administration of intravenous fluids to increase intravascular volume is a frequent intervention in the intensive care unit (ICU), but the choice of resuscitation fluid remains controversial. 1 , 2 Globally, 0.9% sodium chloride (saline) is the most commonly used fluid, although colloids are administered as often as crystalloids, and hydroxyethyl starch (HES) is the most frequently used colloid. 3 Several studies have questioned the safety of HES in critically ill patients, with particular concern that its use increases the risk of acute kidney injury. 4 , 5 Most concern has focused on the use of concentrated HES solutions (10%) with a molecular weight of . . .