UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 25 von 57
Datensatz exportieren als...
BibTeX
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma
Diagnostic cytopathology, 2012-12, Vol.40 (12), p.1047-1053
Miyake, Yasuyuki
Aratake, Yatsuki
Sakaguchi, Takuya
Kiyoya, Kazuaki
Kuribayashi, Tadanobu
Marutsuka, Kousuke
Ohno, Eiji
2012
Details
Autor(en) / Beteiligte
Miyake, Yasuyuki
Aratake, Yatsuki
Sakaguchi, Takuya
Kiyoya, Kazuaki
Kuribayashi, Tadanobu
Marutsuka, Kousuke
Ohno, Eiji
Titel
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma
Ist Teil von
Diagnostic cytopathology, 2012-12, Vol.40 (12), p.1047-1053
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Tumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis. Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thyroid follicular adenoma. Papanicolaou staining, CD26/DPPIV activity staining, and HE staining were performed and the specimens were observed morphologically. Immunohistochemical analysis using antibodies against p53 and PTEN was performed. Genetic mutation of PTEN exons was performed using the laser capture microdissection method. The nuclear area of the CD26/DPPIV‐positive cells was significantly larger than that of the CD26/DPPIV‐negative cells. p53 expression was not observed any specimen. PTEN expression was observed in 18 of 19 cases. DNA sequence analysis did not reveal mutations in exons 5–9 of PTEN in the immunohistochemically PTEN‐negative case. In accordance with our previous reports, we found that observation of concomitant CD26‐positive and PTEN‐negative status in cases of follicular adenoma suggests a state close to follicular carcinoma or progression to cancer, thus warranting careful follow‐up. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-1039
eISSN: 1097-0339
DOI: 10.1002/dc.21725
Titel-ID: cdi_proquest_miscellaneous_1178669813
Format
–
Schlagworte
Adenocarcinoma, Follicular - diagnosis
,
Adenocarcinoma, Follicular - pathology
,
Adenoma - diagnosis
,
Adenoma - pathology
,
Adult
,
Aged
,
CD26/DPPIV
,
Diagnosis, Differential
,
Dipeptidyl Peptidase 4 - genetics
,
Exons
,
Female
,
Gene Expression
,
Humans
,
Immunohistochemistry
,
Laser Capture Microdissection
,
Male
,
Middle Aged
,
Mutation
,
p53
,
PTEN
,
PTEN Phosphohydrolase - genetics
,
thyroid follicular adenoma
,
Thyroid Gland - metabolism
,
Thyroid Gland - pathology
,
Thyroid Neoplasms - diagnosis
,
Thyroid Neoplasms - pathology
,
Tumor Suppressor Protein p53 - genetics
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX