Details

Autor(en) / Beteiligte

• Nielsen, Sune F
• Nordestgaard, Børge G
• Bojesen, Stig E

Titel

Statin Use and Reduced Cancer-Related Mortality

Ist Teil von

• The New England journal of medicine, 2012-11, Vol.367 (19), p.1792-1802

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In a population-based Danish registry study, statin use before a cancer diagnosis reduced cancer-related mortality by 15% across a broad range of cancers. Cholesterol is a fundamental structural component of mammalian cell membranes and is essential for cellular proliferation. 1 , 2 Statins inhibit the production of endogenous cholesterol 3 and block protein prenylation, and statin use may therefore influence cell proliferation and migration. 4 , 5 Cancer-cell proliferation is seen clinically as cancer growth and metastasis, and it ultimately results in the death of the patient. A reduction in the availability of cholesterol could lead to decreased proliferation and migration of cancer cells. 6 , 7 Also, a reduction in the downstream products in the mevalonate pathway due to statin use has been associated with several potential anticancer properties . . .