Details

Autor(en) / Beteiligte

• Santos, Rosimeire F.
• Martins, Italo R.R.
• Monteiro, Fabio de S.
• Travassos, Rafael de A.
• Janebro, Daniele I.
• Tavares, Josean F.
• Silva, Marcelo S.
• da Silva, Bagnólia A.

Titel

Spasmolytic activity of trachylobanes ent-7α-acetoxytrachyloban-18-oic acid and ent-7α-hydroxytrachyloban-18-oic acid isolated from Xylopia langsdorfiana A. St-Hil. & Tul. (Annonaceae)

Ist Teil von

• Natural product research, 2012-12, Vol.26 (24), p.2335-2339

Ort / Verlag

England: Taylor & Francis Group

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• We aimed to investigate the possible spasmolytic activity of ent-7α-acetoxytrachyloban-18-oic acid (1) and ent-7α-hydroxytrachyloban-18-oic acid (2) on smooth muscle models. In male rat aorta and rat uterus, both diterpenes were unable to trigger spasmolytic action. However, 2 relaxed guinea-pig trachea: Compounds 1 and 2 antagonised, significantly and concentration-dependently, carbachol- and histamine-induced phasic contractions in guinea-pig ileum. Moreover, they induced a significant and concentration-dependent relaxation in pre-contracted (KCl, carbachol or histamine) guinea-pig ileum, with 2 being 15 times more potent than 1 in histamine-contracted ileum. These dissimilar results may be due to chemical differences between them. Thus, we demonstrated that 1 and 2 seem to be promising spasmolytic agents, although further studies are required to elucidate the spasmolytic action mechanism.