Nature reviews. Microbiology, 2012-09, Vol.10 (9), p.655-666
2012
Details
- Autor(en) / Beteiligte
- Titel
- Microbial translocation in HIV infection: causes, consequences and treatment opportunities
- Ist Teil von
- Nature reviews. Microbiology, 2012-09, Vol.10 (9), p.655-666
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Systemic immune activation is increased in HIV-infected individuals, even in the setting of virus suppression with antiretroviral therapy. Although numerous factors may contribute, microbial products have recently emerged as potential drivers of this immune activation. In this Review, we describe the intestinal damage that occurs in HIV infection, the evidence for translocation of microbial products into the systemic circulation and the pathways by which these products activate the immune system. We also discuss novel therapies that disrupt the translocation of microbial products and the downstream effects of microbial translocation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1740-1526eISSN: 1740-1534DOI: 10.1038/nrmicro2848Titel-ID: cdi_proquest_miscellaneous_1125255414
- Format
- –
- Schlagworte
- Bacterial Infections - pathology, Bacterial Toxins - immunology, Bacterial Toxins - metabolism, Bacterial Translocation, Care and treatment, Development and progression, Gastrointestinal Tract - immunology, Gastrointestinal Tract - microbiology, Gastrointestinal Tract - pathology, HIV infection, HIV Infections - complications, HIV Infections - immunology, Human immunodeficiency virus, Humans, Immunologic Factors - therapeutic use, Microbial genetics, Models, Biological, Translocation (Genetics)