Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6377-6380
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Zizimauritic acids A–C, three novel nortriterpenes from Ziziphus mauritiana
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6377-6380
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Zizimauritic acids A–C (1–3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1–4 showed cytotoxicities with the IC50 values ranging from 5.05 to 11.94μg/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC50 values 2.17 and 12.79μg/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2012.08.074Titel-ID: cdi_proquest_miscellaneous_1125230093
- Format
- –
- Schlagworte
- acids, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - isolation & purification, Anti-Bacterial Agents - pharmacology, Antibacterial activity, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - pharmacology, betulinic acid, biochemical pathways, Biological and medical sciences, Cell Line, Tumor, chemistry, Cytotoxicity, Humans, Indexing in process, inhibitory concentration 50, Medical sciences, Neoplasms - drug therapy, Nortriterpene, Pharmacology. Drug treatments, Plant Roots - chemistry, roots, Staphylococcal Infections - drug therapy, Staphylococcus aureus, Staphylococcus aureus - drug effects, Triterpenes - chemistry, Triterpenes - isolation & purification, Triterpenes - pharmacology, Zizimauritic acids A–C, Ziziphus - chemistry, Ziziphus mauritiana