Details

Autor(en) / Beteiligte

• Laraia, Erica Martinho Salvador
• Silva, Iandara Schettert
• Pereira, Daniel Martins
• dos Reis, Filipe Abdalla
• Albertini, Regiane
• de Almeida, Patrícia
• Leal Junior, Ernesto Cesar Pinto
• de Tarso Camillo de Carvalho, Paulo

Titel

Effect of Low-Level Laser Therapy (660 nm) on Acute Inflammation Induced by Tenotomy of Achilles Tendon in Rats

Ist Teil von

• Photochemistry and photobiology, 2012-11, Vol.88 (6), p.1546-1550

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• In this study, we aimed to analyze the effects of low‐level laser therapy (LLLT; 660 nm) on levels of protein expression of inflammatory mediators after cutting Achilles tendon of rats. Thirty Wistar male rats underwent partial incisions of the left Achilles tendon, and were divided into three groups of 10 animals according to the time of euthanasia after injury: 6, 24 and 72 h. Each group was then divided into control group and LLLT group (treated with 100 mW, 3.57 W cm−2, 0.028 cm2, 214 J cm−2, 6 J, 60 s, single point). In LLLT group, animals were treated once time per day until the time of euthanasia established for each group. The group treated with LLLT showed a significant reduction of IL‐1β compared with control groups at three time points (6 h: P = 0.0401; 24 h: P = 0.0015; 72 h: P = 0.0463). The analysis of IL‐6 showed significant reduction only in the LLLT group at 72 h compared with control group (P = 0.0179), whereas IL‐10 showed a significant increase in the treated group compared with control group at three experimental times (6 h: P = 0.0007; 24 h: P = 0.0256; 72 h: P < 0.0001). We conclude that LLLT is an important modulator of inflammatory cytokines release after injury in Achilles tendon. The aim of the present study was to investigate the effects of low‐level laser on the acute inflammatory phase following Achilles tendon injury with regard to the expression of pro‐inflammatory and anti‐inflammatory proteins. We conclude that the LLLT InGaAlP (660 nm) 100 mW power and energy of 6 J is an important modulator of inflammatory mediators during the process of tissue repair after injury to the Achilles tendon cutting common Wistar rats.