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The effects of local vanadium treatment on angiogenesis and chondrogenesis during fracture healing
Journal of orthopaedic research, 2012-12, Vol.30 (12), p.1971-1978
Paglia, David N.
Wey, Aaron
Park, Andrew G.
Breitbart, Eric A.
Mehta, Siddhant K.
Bogden, John D.
Kemp, Francis W.
Benevenia, Joseph
O'Connor, J. Patrick
Lin, Sheldon S.
2012
Details
Autor(en) / Beteiligte
Paglia, David N.
Wey, Aaron
Park, Andrew G.
Breitbart, Eric A.
Mehta, Siddhant K.
Bogden, John D.
Kemp, Francis W.
Benevenia, Joseph
O'Connor, J. Patrick
Lin, Sheldon S.
Titel
The effects of local vanadium treatment on angiogenesis and chondrogenesis during fracture healing
Ist Teil von
Journal of orthopaedic research, 2012-12, Vol.30 (12), p.1971-1978
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
This study quantified the effects of local intramedullary delivery of an organic vanadium salt, which may act as an insulin‐mimetic on fracture healing. Using a BB Wistar rat femoral fracture model, local vanadyl acetylacetonate (VAC) was delivered to the fracture site and histomorphometry, mechanical testing, and immunohistochemistry were performed. Callus percent cartilage was 200% higher at day 7 (p < 0.05) and 88% higher at day 10 (p < 0.05) in the animals treated with 1.5 mg/kg of VAC. Callus percent mineralized tissue was 37% higher at day 14 (p < 0.05) and 31% higher at day 21 (p < 0.05) in the animals treated with 1.5 mg/kg of VAC. Maximum torque to failure was 104% and 154% higher at 4 weeks post‐fracture (p < 0.05) for the healing femurs from the VAC‐treated (1.5 and 3.0 mg/kg) animals. Animals treated with other VAC doses demonstrated increased mechanical parameters at 4 weeks (p < 0.05). Immunohistochemistry detected 62% more proliferating cells at days 7 (p < 0.05) and 94% more at day 10 (p < 0.05) in the animals treated with 1.5 mg/kg VAC. Results showed 100% more vascular endothelial growth factor‐C (VEGF‐C) positive cells and 80% more blood vessels at day 7 (p < 0.05) within the callus subperiosteal region of VAC‐treated animals (1.5 mg/kg) compared to controls. The results suggest that local VAC treatment affects chondrogenesis and angiogenesis within the first 7–10 days post‐fracture, which leads to enhanced mineralized tissue formation and accelerated fracture repair as early as 3–4 weeks post‐fracture. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1971–1978, 2012
Sprache
Englisch
Identifikatoren
ISSN: 0736-0266
eISSN: 1554-527X
DOI: 10.1002/jor.22159
Titel-ID: cdi_proquest_miscellaneous_1114954096
Format
–
Schlagworte
Animals
,
BB Wistar rat
,
Bone and Bones - metabolism
,
bone regeneration
,
Cell Proliferation
,
Chondrogenesis - drug effects
,
Femoral Fractures - therapy
,
fracture healing
,
Fracture Healing - drug effects
,
Hydroxybutyrates - pharmacology
,
Immunohistochemistry - methods
,
Insulin - metabolism
,
Male
,
Neovascularization, Physiologic - drug effects
,
Pentanones - pharmacology
,
Rats
,
Rats, Wistar
,
Regeneration
,
Stress, Mechanical
,
Torque
,
vanadium
,
Vanadium - pharmacology
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