Oral oncology, 2012-11, Vol.48 (11), p.1068-1075
2012
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- Autor(en) / Beteiligte
- Titel
- Inflammation linking EMT and cancer stem cells
- Ist Teil von
- Oral oncology, 2012-11, Vol.48 (11), p.1068-1075
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Summary Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial–mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal–epithelial transition (MET). Such changes allow the tumor to compete with the normal microenvironment to overcome anti-tumorigenic pressures. Then, once tissue homeostasis is lost, the altered microenvironment, like that accompanying inflammation, can itself become a potent tumor promoter. This review will discuss the changes that cancer cells undergo in converting from EMT to CSCs in an inflammation microenvironment, to understand the mechanisms behind invasion and metastasis and provide insights into prevention of metastasis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1368-8375eISSN: 1879-0593DOI: 10.1016/j.oraloncology.2012.06.005Titel-ID: cdi_proquest_miscellaneous_1114953676
- Format
- –
- Schlagworte
- Biological and medical sciences, Biomarkers, Tumor - biosynthesis, Cancer stem cells (CSCs), Cell Transformation, Neoplastic - metabolism, Cell Transformation, Neoplastic - pathology, Cytokines - metabolism, Epithelial-Mesenchymal Transition - physiology, Epithelial–mesenchymal transition (EMT), Hematology, Oncology and Palliative Medicine, Humans, Inflammation - metabolism, Inflammation - pathology, Inflammation microenvironment, Medical sciences, Neoplasm Invasiveness - pathology, Neoplasm Metastasis - pathology, Neoplastic Stem Cells - pathology, Otolaryngology, Otorhinolaryngology. Stomatology, Tumor Microenvironment, Tumors