Details

Autor(en) / Beteiligte

• Wu, Lian-Ming, MD
• Xu, Jian-Rong, MD, PhD
• Gu, Hai-Yan, MD
• Hua, Jia, MD
• Chen, Jie, MD
• Zhang, Wei, MD, PhD
• Haacke, E. Mark, PhD
• Hu, Jiani, PhD

Titel

Preoperative mediastinal and hilar nodal staging with diffusion-weighted magnetic resonance imaging and fluorodeoxyglucose positron emission tomography/computed tomography in patients with non–small-cell lung cancer: Which is better?

Ist Teil von

• The Journal of surgical research, 2012-11, Vol.178 (1), p.304-314

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Background To compare the diagnostic capability of diffusion-weighted magnetic resonance imaging (DWI) and18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in the N stage assessment in patients with non–small-cell lung cancer. Methods We performed a meta-analysis of all available studies of the diagnostic performance of DWI and18 F-FDG PET/CT in the N stage assessment of patients with non–small-cell lung cancer. We determined the sensitivity and specificity across studies, calculated the positive and negative likelihood ratios (LR+ and LR−, respectively), and constructed the summary receiver operating characteristic curves using hierarchical regression models. The methodologic quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Results A total of 19 studies met the inclusion criteria and included a total of 2845 pathologically confirmed patients. No publication bias was found. The methodologic quality was relatively high. The pooled sensitivity estimate of DWI (0.72, 95% confidence interval [CI] 0.63–0.80) was not significantly difference between PET/CT (0.75, 95% CI 0.68–0.81; P = 0.09). The pooled specificity estimate for DWI (0.95, 95% CI 0.85–0.98) was significantly greater than18 F-FDG PET/CT (0.89, 95% CI 0.85–0.91; P = 0.02). For DWI, the overall LR+ was 13.80 (95% CI 4.54–41.95) and the LR− was 0.29 (95% CI 0.21–0.40). For18 F-FDG PET/CT, LR+ was 6.67 (95% CI 5.20–8.56) and LR− was 0.28 (95% CI 0.22–0.37). Conclusions Our study has confirmed that DWI has a high specificity for N staging of non–small-cell lung cancer compared with18 F-FDG PET/CT and has the potential to be a reliable alternative noninvasive imaging method for the preoperative staging of mediastinal and hilar lymph nodes in patients with non–small-cell lung cancer.