Details

Autor(en) / Beteiligte

• Savoye, Guillaume
• Salleron, Julia
• Gower‐Rousseau, Corinne
• Dupas, Jean‐Louis
• Vernier‐Massouille, Gwénola
• Fumery, Mathurin
• Merle, Véronique
• Lerebours, Eric
• Cortot, Antoine
• Turck, Dominique
• Salomez, Jean‐Louis
• Lemann, Marc
• Colombel, Jean‐Frédéric
• Duhamel, Alain

Titel

Clinical predictors at diagnosis of disabling pediatric Crohn's disease

Ist Teil von

• Inflammatory bowel diseases, 2012-11, Vol.18 (11), p.2072-2078

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2012

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background: Identification of children with Crohn's disease (CD) at high risk of disabling disease would be invaluable in guiding initial therapy. Our study aimed to identify predictors at diagnosis of a subsequent disabling course in a population‐based cohort of patients with pediatric‐onset CD. Methods: Among 537 patients with pediatric CD diagnosed at <17 years of age, 309 (57%) with 5‐year follow‐up were included. Clinical and demographic factors associated with subsequent disabling CD were studied. Three definitions of disabling CD were used: Saint‐Antoine and Liège Hospitals' definitions and a new pediatric definition based on the presence at maximal follow‐up of: 1) growth delay defined by body mass index (BMI), weight or height lower than −2 SD Z score; and 2) at least one intestinal resection or two anal interventions. Predictors were determined using multivariate analyses and their accuracy using the kappa method considering a relevant value ≥0.6. Results: According to the Saint‐Antoine definition, the rate of disabling CD was 77% and predictors were complicated behavior and L1 location. According to the Liège definition, the rate was 37% and predictors included behavior, upper gastrointestinal disease, and extraintestinal manifestations. According to the pediatric definition, the rate of disabling CD was 15%, and predictors included complicated behavior, age <14, and growth delay at diagnosis. Kappa values for each combination of predictors were, respectively, 0.2, 0.3, and 0.2 and were nonrelevant. Conclusions: Clinical parameters at diagnosis are insufficient to predict a disabling course of pediatric CD. More complex models including serological and genetic biomarkers should be tested. (Inflamm Bowel Dis 2012;)