Details

Autor(en) / Beteiligte

• Van der Bij, A.K.
• Van der Zwan, D.
• Peirano, G.
• Severin, J.A.
• Pitout, J.D.D.
• Van Westreenen, M.
• Goessens, W.H.F.

Titel

Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type

Ist Teil von

• Clinical microbiology and infection, 2012-09, Vol.18 (9), p.E369-E372

Ort / Verlag

Oxford, UK: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

Wiley Online Library Journals【Remote access available】

Beschreibungen/Notizen

• Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as STI11 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.