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BibTeX
Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature
Journal of bone and mineral research, 2012-09, Vol.27 (9), p.1967-1975
Jiang, Yan
Xia, Wei-bo
Xing, Xiao-ping
Silva, Barbara C
Li, Mei
Wang, Ou
Zhang, Hua-bing
Li, Fang
Jing, Hong-li
Zhong, Ding-rong
Jin, Jin
Gao, Peng
Zhou, Lian
Qi, Fang
Yu, Wei
Bilezikian, John P
Meng, Xun-wu
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Jiang, Yan
Xia, Wei-bo
Xing, Xiao-ping
Silva, Barbara C
Li, Mei
Wang, Ou
Zhang, Hua-bing
Li, Fang
Jing, Hong-li
Zhong, Ding-rong
Jin, Jin
Gao, Peng
Zhou, Lian
Qi, Fang
Yu, Wei
Bilezikian, John P
Meng, Xun-wu
Titel
Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature
Ist Teil von
Journal of bone and mineral research, 2012-09, Vol.27 (9), p.1967-1975
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Tumor‐induced osteomalacia (TIO) is an acquired form of hypophosphatemia. Tumor resection leads to cure. We investigated the clinical characteristics of TIO, diagnostic methods, and course after tumor resection in Beijing, China, and compared them with 269 previous published reports of TIO. A total of 94 patients with adult‐onset hypophosphatemic osteomalacia were seen over a 6‐year period (January, 2004 to May, 2010) in Peking Union Medical College Hospital. After physical examination (PE), all patients underwent technetium‐99m octreotide scintigraphy (99Tcm‐OCT). Tumors were removed after localization. The results demonstrated that 46 of 94 hypophosphatemic osteomalacia patients had high uptake in 99Tcm‐OCT imaging. Forty of them underwent tumor resection with the TIO diagnosis established in 37 patients. In 2 patients, the tumor was discovered on PE but not by 99Tcm‐OCT. The gender distribution was equal (M/F = 19/20). Average age was 42 ± 14 years. In 35 patients (90%), the serum phosphorus concentration returned to normal in 5.5 ± 3.0 days after tumor resection. Most of the tumors (85%) were classified as phosphaturic mesenchymal tumor (PMT) or mixed connective tissue variant (PMTMCT). Recurrence of disease was suggested in 3 patients (9%). When combined with the 269 cases reported in the literature, the mean age and sex distribution were similar. The tumors were of bone (40%) and soft tissue (55%) origins, with 42% of the tumors being found in the lower extremities. In summary, TIO is an important cause of adult‐onset hypophosphatemia in China. 99Tcm‐OCT imaging successfully localized the tumor in the overwhelming majority of patients. Successful removal of tumors leads to cure in most cases, but recurrence should be sought by long‐term follow‐up. © 2012 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.1642
Titel-ID: cdi_proquest_miscellaneous_1069194891
Format
–
Schlagworte
Adult
,
Age
,
Age composition
,
Age of Onset
,
Aged
,
Biological and medical sciences
,
Bone tumors
,
China - epidemiology
,
Connective tissues
,
Female
,
FIBROBLAST GROWTH FACTOR-23
,
Fibroblast Growth Factors - blood
,
Follow-Up Studies
,
Fundamental and applied biological sciences. Psychology
,
Hospitals
,
Humans
,
HYPOPHOSPHATEMIA
,
Hypophosphatemia - blood
,
Hypophosphatemia - epidemiology
,
Hypophosphatemia - etiology
,
Hypophosphatemia - pathology
,
imaging
,
Literature reviews
,
Male
,
Mesenchyme
,
Middle Aged
,
Neoplasms, Connective Tissue - blood
,
Neoplasms, Connective Tissue - complications
,
Neoplasms, Connective Tissue - pathology
,
Neoplasms, Connective Tissue - surgery
,
octreotide
,
Osteomalacia
,
Phosphorus
,
Phosphorus - blood
,
Scintigraphy
,
Sex
,
Skeleton and joints
,
Soft tissues
,
TECHNETIUM-99M OCTREOTIDE SCINTIGRAPHY
,
TUMOR-INDUCED OSTEOMALACIA
,
Tumors
,
Vertebrates: osteoarticular system, musculoskeletal system
,
Young Adult
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