Medical hypotheses, 2012-10, Vol.79 (4), p.504-507
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Methoxetamine: From drug of abuse to rapid-acting antidepressant
- Ist Teil von
- Medical hypotheses, 2012-10, Vol.79 (4), p.504-507
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Abstract Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that methoxetamine can produce rapid antidepressant effects in patients with resistant and non-resistant unipolar and bipolar depression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-9877eISSN: 1532-2777DOI: 10.1016/j.mehy.2012.07.002Titel-ID: cdi_proquest_miscellaneous_1039037499
- Format
- –
- Schlagworte
- Anesthetics, Dissociative - pharmacology, Animals, Antidepressive Agents - pharmacology, Bipolar Disorder - drug therapy, Cyclohexanones - pharmacology, Cyclohexylamines - pharmacology, Depressive Disorder - drug therapy, Humans, Internal Medicine, Ketamine - pharmacology, Models, Biological, Receptors, Muscarinic - drug effects, Receptors, N-Methyl-D-Aspartate - drug effects, Receptors, Opioid - drug effects, Receptors, sigma - drug effects, Street Drugs - pharmacology