Pharmazie, 2012-08, Vol.67 (8), p.742-743
2012
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Dermal absorption of amorphous nanosilica particles after topical exposure for three days
- Ist Teil von
- Pharmazie, 2012-08, Vol.67 (8), p.742-743
- Ort / Verlag
- Germany: Govi-Verlag
- Erscheinungsjahr
- 2012
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The skin penetration and cellular localization of welldispersed amorphous nanosilica particles (nSPs) with a diameter of 70 nm was analyzed in mice. Our results suggest that after topical exposure for three days the particles penetrate the skin barrier and are transported to the lymph nodes. These findings underscore the need to examine biological effects following dermal exposure to nSPs for the development of safer use of nSPs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0031-7144DOI: 10.1691/ph.2012.1853Titel-ID: cdi_proquest_miscellaneous_1039036528
- Format
- –
- Schlagworte
- Administration, Cutaneous, Administration, Topical, Animals, Ear, External - metabolism, Mice, Mice, Inbred BALB C, Microscopy, Electron, Transmission, Nanoparticles - administration & dosage, Silicon Dioxide - administration & dosage, Silicon Dioxide - pharmacokinetics, Skin Absorption - physiology, Suspensions