Details

Autor(en) / Beteiligte

• Taylor, Craig J.
• Peacock, Sarah
• Chaudhry, Afzal N.
• Bradley, J. Andrew
• Bolton, Eleanor M.

Titel

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

Ist Teil von

• Cell stem cell, 2012-08, Vol.11 (2), p.147-152

Ort / Verlag

Cambridge, MA: Elsevier Inc

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.