Details

Autor(en) / Beteiligte

• Lee, Ji Hwan
• Lee, Woojung
• Lee, Seungyong
• Jung, Yujung
• Park, Soon-Hye
• Choi, Pilju
• Kim, Su-Nam
• Ham, Jungyeob
• Kang, Ki Sung

Titel

Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5475-5479

Ort / Verlag

Amsterdam: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Maillard reaction is significantly involved in the increased antioxidant effect of ginsenoside Re-serine mixture by heat-processing. The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg2, Rg6 and F4 by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage.